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MSC-based clinical trials for nerve injury and spinal cord injury (SCI).

Journal: Regenerative Therapy

Article Title: Beyond conventional therapies: MSCs in the battle against nerve injury

doi: 10.1016/j.reth.2024.12.017

Figure Lengend Snippet: MSC-based clinical trials for nerve injury and spinal cord injury (SCI).

Article Snippet: An Indian company known as Stempeutics conducted a phase 4 clinical trial in September 2021, and the results indicated that Stempeucel's allogeneic BM-MSCs product was safe, effective, and had positive, long-lasting effects that not only reduced pain but aided in ulcer healing for severe limb ischemia triggered by Buerger's disease.

Techniques: Clinical Proteomics, Transplantation Assay, Derivative Assay, Diffusion-based Assay, Imaging, Membrane, Cell Culture, Injection

Main characteristics of the included clinical trials.

Journal: Journal of Orthopaedic Translation

Article Title: Advanced therapy with mesenchymal stromal cells for knee osteoarthritis: Systematic review and meta-analysis of randomized controlled trials

doi: 10.1016/j.jot.2024.07.012

Figure Lengend Snippet: Main characteristics of the included clinical trials.

Article Snippet: 7 , Gupta 2016 [ ] , India , N = 60 Mean age between 54.00 ± 6.73 and 58.10 ± 8.2 years KL grade II-III KOA , Allogeneic BM-MSC (four groups with 5, 50, 75, or 150 × 10 6 cells) + VS N = 10 , Placebo N = 5 , Adverse events Serious adverse events VAS WOMAC ICOAP WORMS X-ray , Up to 2 years , Stempeutics Research Pvt. Ltd. Protocol registration reported (NCT01453738).

Techniques: Comparison, Control

Main characteristics of the included clinical trials.

Journal: Journal of Orthopaedic Translation

Article Title: Advanced therapy with mesenchymal stromal cells for knee osteoarthritis: Systematic review and meta-analysis of randomized controlled trials

doi: 10.1016/j.jot.2024.07.012

Figure Lengend Snippet: Main characteristics of the included clinical trials.

Article Snippet: 8 , Gupta 2022 [ ] , India , N = 146 Mean age of 40–60 years KL grade II-III KOA , Allogenic BM-MSC (25 × 10 6 cells) + VS N = 73 , VS N = 73 , Adverse events Serious adverse events WOMAC VAS MRI , Up to 12 months , Stempeutics Research Pvt LtdProtocol registration reported (CTRI/2018/09/015785).

Techniques: Comparison, Control

Cartilage-related clinical trials using iPSC-MSCs and chondrocytes

Journal: Stem Cell Research & Therapy

Article Title: iPSCs chondrogenic differentiation for personalized regenerative medicine: a literature review

doi: 10.1186/s13287-024-03794-1

Figure Lengend Snippet: Cartilage-related clinical trials using iPSC-MSCs and chondrocytes

Article Snippet: In 2020, the University of Sydney and Cynata Therapeutics conducted phase 1 clinical trial to evaluate the safety, efficacy, and cost-effectiveness of an allogenic MSCs therapy (Cymerus MSCs) for tibiofemoral knee OA [ ].

Techniques: Clinical Proteomics, Injection

Papers assessing the use of cell therapies in acute fracture care

Journal: Journal of Orthopaedics and Traumatology : Official Journal of the Italian Society of Orthopaedics and Traumatology

Article Title: Cellular therapies for bone repair: current insights

doi: 10.1186/s10195-024-00768-0

Figure Lengend Snippet: Papers assessing the use of cell therapies in acute fracture care

Article Snippet: Jayankura et al. 2021 [ ] , Percutaneous injection of allogenic MSCs into long-bone delayed union , Tibia—8 Humerus—5 Femur—3 Ulna—3 Fibula—2 Radius—1 , 6.6 months , Allogenic MSCs (ALLOB, Bone Therapeutics) , Nil Original fixation retained.

Techniques: Injection, Cell Culture

Papers assessing the use of cell therapy in nonunion

Journal: Journal of Orthopaedics and Traumatology : Official Journal of the Italian Society of Orthopaedics and Traumatology

Article Title: Cellular therapies for bone repair: current insights

doi: 10.1186/s10195-024-00768-0

Figure Lengend Snippet: Papers assessing the use of cell therapy in nonunion

Article Snippet: Jayankura et al. 2021 [ ] , Percutaneous injection of allogenic MSCs into long-bone delayed union , Tibia—8 Humerus—5 Femur—3 Ulna—3 Fibula—2 Radius—1 , 6.6 months , Allogenic MSCs (ALLOB, Bone Therapeutics) , Nil Original fixation retained.

Techniques: Injection, Membrane

Papers assessing the use of cell therapy in the management of bone defects

Journal: Journal of Orthopaedics and Traumatology : Official Journal of the Italian Society of Orthopaedics and Traumatology

Article Title: Cellular therapies for bone repair: current insights

doi: 10.1186/s10195-024-00768-0

Figure Lengend Snippet: Papers assessing the use of cell therapy in the management of bone defects

Article Snippet: Jayankura et al. 2021 [ ] , Percutaneous injection of allogenic MSCs into long-bone delayed union , Tibia—8 Humerus—5 Femur—3 Ulna—3 Fibula—2 Radius—1 , 6.6 months , Allogenic MSCs (ALLOB, Bone Therapeutics) , Nil Original fixation retained.

Techniques: Injection, Blocking Assay

Miscellaneous papers assessing the use of cell therapy

Journal: Journal of Orthopaedics and Traumatology : Official Journal of the Italian Society of Orthopaedics and Traumatology

Article Title: Cellular therapies for bone repair: current insights

doi: 10.1186/s10195-024-00768-0

Figure Lengend Snippet: Miscellaneous papers assessing the use of cell therapy

Article Snippet: Jayankura et al. 2021 [ ] , Percutaneous injection of allogenic MSCs into long-bone delayed union , Tibia—8 Humerus—5 Femur—3 Ulna—3 Fibula—2 Radius—1 , 6.6 months , Allogenic MSCs (ALLOB, Bone Therapeutics) , Nil Original fixation retained.

Techniques: Injection